Blar i forfatter "Zhang, Lian-Hui"

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    • Microevolution of the mexT and lasR Reinforces the Bias of Quorum Sensing System in Laboratory Strains of Pseudomonas aeruginosa PAO1 

      Liu, Yang; Ahator, Stephen Dela; Wang, Huishan; Feng, Qishun; Xu, Yinuo; Li, Chuhao; Zhou, Xiaofan; Zhang, Lian-Hui (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-12)
      The Pseudomonas aeruginosa strain PAO1 has routinely been used as a laboratory model for quorum sensing (QS). However, the microevolution of P. aeruginosa laboratory strains resulting in genetic and phenotypic variations have caused inconsistencies in QS research. To investigate the underlying causes of these variations, we analyzed 5 Pseudomonas aeruginosa PAO1 sublines from our laboratory using a ...

    • Nutrient Availability and Phage Exposure Alter the Quorum-Sensing and CRISPR-Cas-Controlled Population Dynamics of Pseudomonas aeruginosa 

      Ahator, Stephen Dela; Sagar, Sadhanna; Zhu, Minya; Wang, Jianhe; Zhang, Lian-Hui (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-14)
      Quorum sensing (QS) coordinates bacterial communication and cooperation essential for virulence and dominance in polymicrobial settings. QS also regulates the CRISPR-Cas system for targeted defense against parasitic genomes from phages and horizontal gene transfer. Although the QS and CRISPR-Cas systems are vital for bacterial survival, they undergo frequent selection in response to biotic and abiotic ...

    • The virulence factor regulator and quorum sensing regulate the type I-F CRISPR-Cas mediated horizontal gene transfer in Pseudomonas aeruginosa 

      Ahator, Stephen Dela; Liu, Yang; Wang, Jianhe; Zhang, Lian-Hui (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-30)
      Pseudomonas aeruginosa is capable of thriving in diverse environments due to its network of regulatory components for effective response to stress factors. The survival of the bacteria is also dependent on the ability to discriminate between the acquisition of beneficial and non-beneficial genetic materials via horizontal gene transfer (HGT). Thus, bacteria have evolved the CRISPR-Cas adaptive immune ...